가토 두개골 결손부에 이식된 저골(猪骨)과 혈소판 풍부 섬유소의 골형성 효과
The Effect of Porcine Cancellous Bone for Bone Regeneration and Application of Platelet-rich Fibrin in Rabbit Calvarial Defect
박정익, 전성배, 송영일, 도형식, 이진용, 장현석, 권종진, 임재석, 이의석,
소속 상세정보
박정익 ( Park Jeong-Ik ) - 고려대학교 의과대학 구강악안면외과학교실
전성배 ( Jeon Seong-Bae ) - 고려대학교 의과대학 구강악안면외과학교실
송영일 ( Song Young-Il ) - 고려대학교 의과대학 구강악안면외과학교실
도형식 ( Do Hyoung-Sik ) - 고려대학교 의과대학 구강악안면외과학교실
이진용 ( Lee Jin-Yong ) - 고려대학교 의과대학 구강악안면외과학교실
장현석 ( Jang Hyon-Seok ) - 고려대학교 의과대학 구강악안면외과학교실
권종진 ( Kwon Jong-Jin ) - 고려대학교 의과대학 구강악안면외과학교실
임재석 ( Rim Jae-Suk ) - 고려대학교 의과대학 구강악안면외과학교실
이의석 ( Lee Eui-Seok ) - 고려대학교 의과대학 구강악안면외과학교실
KMID : 0360120120340060391
Abstract
Purpose: The purpose of this study was to evaluate the effectiveness of the platelet-rich fibrin (PRF) used in combination with the porcine cancellous bone as a scaffold, in promoting bone regeneration in the bone defects ofthe rabbit calvaria.
Methods: Ten rabbits were used in the study. Three round-shaped defects (diameter 8.0 mm) were created in the rabbit calvaria and were filled with nothing (control group), porcine cancellousbone (Experimental Group 1, porcine bone) and PRF-mixed porcine cancellous bone (Experimental Group 2). TS-GBB is a xenogenic bone-substitute product comprised of a high heat-treated mineralized porcine cancellous bone. Animals were sacrificed at 6 weeks and 12 weeks for the histological and radiographic evaluations.
Results: In the micro computed tomography and histological results, the experimental groups 1 and 2 showed more bone formation, remodeling, and calcification than the control group. The new bone formation ratio showed theGroup 2 to be larger than Group 1 at6 and 12 weeks. However, there was no significant difference between the experimental groups 1 and 2 in the new bone formation area, at the 6 and 12 weeks (P>0.05).
Conclusion: The PRF-mixed group showed more bone formation than the porcine cancellousbonegroup (TS-GBB), butthere was a no significant difference. The PRF may not lead to enhanced bone healing when grafted with the porcine cancellous bone.
키워드
Xenograft;Bone regeneration
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